Klinefelter’s syndrome is a sex chromosome disorder in males due to presence of one or more extra X chromosome.
- Nondisjunction or error during division of egg or sperm
Severity of symptoms depends upon the number of cells affected and also upon the number of extra X chromosomes in each cell. Symptoms may include:
- Small testicles
- Enlarged breasts
- Less than normal body hair
- Tall height
- Weak muscles and bones
- Language problems
- Sensitive and shy temperament
There is no cure for this syndrome but symptoms may be managed by:
- Testosterone replacement treatment (TRT) to bring testosterone levels to normal limit to increase body hair, deepen voice and develop muscle tone
- Physical therapy to strengthen muscles
- Speech therapy to improve expression and understanding of conversation
- Special education techniques to improve classroom learning
There is no prevention for this syndrome.