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Klinefelter’s Syndrome


Klinefelter’s syndrome is a sex chromosome disorder in males due to presence of one or more extra X chromosome.


  • Nondisjunction or error during division of egg or sperm

Severity of symptoms depends upon the number of cells affected and also upon the number of extra X chromosomes in each cell. Symptoms may include:

  • Infertility
  • Small testicles
  • Enlarged breasts
  • Less than normal body hair
  • Tall height
  • Weak muscles and bones
  • Language problems
  • Sensitive and shy temperament

There is no cure for this syndrome but symptoms may be managed by:

  • Testosterone replacement treatment (TRT) to bring testosterone levels to normal limit to increase body hair, deepen voice and develop muscle tone
  • Physical therapy to strengthen muscles
  • Speech therapy to improve expression and understanding of conversation
  • Special education techniques to improve classroom learning


There is no prevention for this syndrome.